DNMT1 and central nervous system cancer: DNMT1 (known as the maintenance DNMT) has a high preference for hemimethylated DNA substrates and is essential for maintaining methylation patterns and accurately replicating genomic DNA methylation patterns during cell division in mammalian cells.22 DNMT1 was demonstrated to exhibit a positive correlation with cancer cell chemoresistance in various tumors.23 Therefore, we evaluated its role in the development of glioma chemotherapy resistance.