miR-20a was capable of enhancing the invasiveness of CD133+ glioma stem cells (GSCs) isolated from both the U87 glioblastoma cell line and primary human glioma specimens.26 In addition, the miR-20a-mediated downregulation of NKG2D ligands contributed to glioma immune escape.17 Based on the observation that decreased DNMT1 expression was associated with increased miR-20a expression in physiological processes associated with glioblastoma chemoresistance, miR-20a was recognized as a potential key factor for DNMT1-controlled glioma chemoresistance. This evidence concerns the gene PROM1 and glioblastoma.