Phospho-S27-Ku70 may matche with phospho-S2056-DNA-PKcs localization at sites of DNA damage only transitory and early after genotoxic stress in primary R-CLL cells (Figure 5A) while the colocalisation with γ-H2AX was not evident in wholly irradiated cells since pS27-Ku70 progressively increased in nuclear area without clear large foci formation (Figure 5B and Supplementary Figure S3, upper panel). The gene discussed is XRCC6; the disease is B-cell chronic lymphocytic leukemia.