It was hypothesized that cytokines as IL-1, IL-6, IFN-γ, TNF-α, brain-derived neurotrophic factor, MIC-1 may be involved in the cachexia process, in the imbalance which favors catabolism over anabolism, and in the neurologic and neuropsychiatric manifestations of the disease. The gene discussed is BDNF; the disease is Cachexia.