It was hypothesized that cytokines as IL-1, IL-6, IFN-γ, TNF-α, brain-derived neurotrophic factor, MIC-1 may be involved in the cachexia process, in the imbalance which favors catabolism over anabolism, and in the neurologic and neuropsychiatric manifestations of the disease. This evidence concerns the gene TNF and Cachexia.