In the present analysis, we have applied the SDR methodology for identifying a genetic profile consisting of the combination between specific VEGFR-2 (rs2071559, rs11133360) and P2X7R (rs3751143, rs208294) genotypes associated with a greater OS as compared to that observed in the whole study population, in an unselected population of patients with prostate cancer. This evidence concerns the gene KDR and prostate carcinoma.