Interestingly, Wei and colleagues [39] demonstrated that the chronic exposure of C6 glioma cells to 2′,3′-(benzoyl-4-benzoyl)-ATP (BzATP), a selective P2X7R agonist, enhanced the expression of pro-inflammatory and angiogenic factors, including IL-8 and VEGF, suggesting a link between the receptor activation, inflammation, increased angiogenesis and tumor cell migration. The gene discussed is VEGFA; the disease is central nervous system cancer.