Quantitative RT-PCR and Western blot analysis showed increased E-cadherin expression and reduced N-cadherin and Snail levels predominantly in SAS cells, but not in FaDu and OECM1 cells, cultivated in a lower-glucose medium providing a potential mechanistic cue of glucose-mediated regulation for HNSCC cell motility (Figure 2E, 2F and Supplementary Figure S3A). The gene discussed is CDH2; the disease is head and neck squamous cell carcinoma.