In addition to Cytochrome c mediated apoptosis and Akt/AMPK-mTORC pathways, the molecular cues differentially expressed in HNSCC cells under low- and high-glucose environments revealed by human antibody array analysis (Supplementary Figure S4C) could also be important glycemia-mediated malignant determinants. The gene discussed is PRKAA1; the disease is head and neck squamous cell carcinoma.