PPP2R2B and ductal breast carcinoma in situ: As far as PPP2R2B is concerned, recent studies show that its promoter is methylated in colorectal cancer (Tan et al. 2010), ductal carcinoma in situ, and early invasive breast cancer (Muggerud et al. 2010), as well as laryngeal squamous cell carcinoma (Paluszczak et al. 2014).