As far as PPP2R2B is concerned, recent studies show that its promoter is methylated in colorectal cancer (Tan et al. 2010), ductal carcinoma in situ, and early invasive breast cancer (Muggerud et al. 2010), as well as laryngeal squamous cell carcinoma (Paluszczak et al. 2014). This evidence concerns the gene PPP2R2B and invasive breast carcinoma.