These are H19, a lncRNA encoded by an imprinted gene that exhibits remarkably elevated levels in a large number of human cancers [32]; ANRIL, which is located at the tumor suppressor locus encoding p16INK4A and p15INK4B and represses the expression of these two tumor suppressors [21, 34, 49]; and ERIC, which was shown to regulate apoptosis that is induced by either E2F1 or DNA damage [33]. Here, E2F1 is linked to cancer.