EDN3 and type 2 diabetes mellitus: As depicted in Table 1 and Figure 1, two genes OLIG1 and BAG3 were highly up-regulated and eight genes PRDM16, GLDNA, APOA1, CCKBR, EDN3, VAV3, CXCR4, and GHRL were down regulated in pancreas with T2D as compared to pancreas control.