EWSR1 and Ewing sarcoma: We found a significant enrichment of our ChIP-seq-defined EWS/FLI1 target genes in the category of genes with high levels of H3K27Ac binding signal in their enhancer regions (Figure 1G and Supplementary Figure S1D), consistent with enrichment of this oncogenic transcription factor at super-enhancers in Ewing sarcoma.