MTHFR and metabolic syndrome: In this study, we aim to explore the independent associations of folate, Hcy and these four gene polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) on serum lipid profiles, as well as to evaluate the joint effect of gene, Hcy and genotypes on dyslipidemia in Chinese hypertensive patients.