In trend test, all these gene polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) with low folate increased the prevalence of hypertriglyceridemia (interaction of MTHFR C677T and folate: P = 0.049; interaction of MTHFR A1298C and folate: P = 0.004; interaction of MTR A2756G and folate: P = 0.007; interaction of MTRR A66G and folate: P = 0.005, respectively). This evidence concerns the gene MTHFR and hypertriglyceridemia.