TP53 and neoplasm: A curious detail regarding the origin of most ovarian HGSC in patients with HBOC, suggested by recent studies of prophylactically removed ovaries, is that instead of arising primarily from the ovary as originally assumed, these tumours actually seem to arise from the fallopian tube fimbriae and are characterized by p53 signature mutations, typical of tubal intraepithelial carcinomas.