Even though cases of NHD/PLOSL have been described since the 1960s, it wasn’t until the late 1990s that inheritance of the disease was linked to chromosomal region 19q13 [8], and subsequent analysis identified a large chromosomal deletion (exons 1–4) of TYROBP, the gene encoding DAP12 [9]. The gene discussed is TYROBP; the disease is Nasu-Hakola disease.