Unlike non-mutated TREM2, expression of the TREM2 variants p.T66M and p.Y38C (associated with genetic risk of FTD [12, 16]) in HEK293 or BV2 microglial cells, led to accumulation of immature, membrane-bound TREM2 species (~36 kDa). This evidence concerns the gene TREM2 and frontotemporal dementia.