On the other hand, human endosialin/TEM1 overexpression has been observed in many cancer cells of various tissue origins, including the colon, breast, pancreas, and lung 7; however, no report has focused on the expression of TEM1 in both cancer and stromal cells in human cancer tissue, nor have the clinical implications, such as the effect on overall survival (OS) and recurrence-free survival (RFS), especially in patients with gastric cancer, been examined. This evidence concerns the gene CD248 and cancer.