Surprisingly, it appears that FANCJ regulates FANCD2 stability through 2 separate pathways, as both MG-132 and Z-VAD-FMK restored FANCD2 levels to near normal levels in H1299 lung cancer cells (84% and 93% of normal, respectively; Figure 5A and 5B). The gene discussed is FANCD2; the disease is lung carcinoma.