As cell lines used were originated from different tissue origins, eg., HDF cells are human dermal fibroblasts (1A), A549 (1B) and H1299 (1C) are non-small cell lung cancer cell lines, OV90 (1D) and SKOV3 (1E) are ovarian cancer cell lines, these results suggest FANCJ status is important for the stability or expression of FANCD2 and FANCI proteins in a variety of cell types. The gene discussed is BRIP1; the disease is ovarian carcinoma.