Intriguingly, however, depletion of FOXA1 in several PC cell lines is not deleterious to all AR binding events at shared androgen response element (ARE) and FOXA1-binding sites, and a concurrent stimulation of receptor binding to new AREs within the genome suggest that FOXA1 may function to both facilitate and repress AR signalling at discriminate genomic loci [16, 19]. This evidence concerns the gene FOXA1 and pachyonychia congenita.