Further analysis of mutations or alterations in breast cancer samples using cBioPortal (http://www.cbioportal.org/public-portal/index.do) [16, 17] indicated that EVL expression is downregulated (homozygous deletion or mRNA downregulation) mainly in basal-like and HER2 enriched tumors; ENAH expression is increased by mRNA upregulation or gene amplification and this was not specific to a breast cancer subtype (Fig. 1B). The gene discussed is ERBB2; the disease is breast cancer.