MYC and preeclampsia: Moreover, the invasiveness of JEG-3 cells were largely dependent on the level of MYC protein, which was regulated by miR-34a, suggesting that targeting MYC by miR-34a may play a critical role in the regulation of trophoblast invasion, and that excessive suppression of MYC translation by miR-34a may result in inadequate trophoblast invasion and the development of preeclampsia.