At present, it is known that mutant Huntingtin (HTT) aggregates localise in the axons as well as in neurons (Li et al., 2001, Li, 1999, Sinadinos et al., 2009), with evidence to show disrupted axonal transport in HD (Li et al., 2001, Li and Conforti, 2013, Sinadinos et al., 2009). Here, HTT is linked to Huntington disease.