Down-regulating expression of HSP60A, HSP60B orHSP60C in photoreceptors suppressed the FUS-induced retinal degeneration phenotype to various extents, with siHSP60B showing the most robust effect, although knocking-down HSP60 did not affect the expression level of FUS (see S5A and S5B Fig). This evidence concerns the gene FUS and retinal degeneration.