FUS and amyotrophic lateral sclerosis: Because no FUS mutation has been detected in most FTLD-FUS patients and because the patient samples that we examined showed elevated FUS protein levels (see below), the work in this study examining the effects of increased Wt-FUS expression is pertinent to understanding FTLD-FUS, whereas the data with ALS-mutant FUS, such as P525L, is relevant to ALS-FUS.