The biochemical signatures of acquired CNDDs and sCNDDs (Table 1 and Fig 3) showed the following patterns: (a) lowest ages at peak incidences for PrP-related ailments, ranging from 20–24 to 75–79 years for vCJD, atCJD and sCJD; (b) a medium age-at-onset interval peaking from 75 to 85 years for MAPT, FUSS, SOD 1 (frequent in ALS and FTD); and, (c) highest age at peak incidence for pathologies associated with α-synuclein, mixed α-synuclein+tau and Aβ+tau. Here, MAPT is linked to amyotrophic lateral sclerosis.