These proteins are summarized in Table 2 and included titin (gi|407139), PRO2619 (gi|11493459), forkhead transcription activator homolog (gi|477361, FHK 5–3), ryanodine receptor 2 isoform CRA_c (gi|119590477), plectin 1 intermediate filament binding protein (gi|119602578), keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris, gi|119581085), keratin 10 (gi|186629), keratin 10 (gi|119581085), titin (gi|407139), and leucine zipper protein 5 isoform CRA_b (gi|119624991). The gene discussed is TTN; the disease is epidermolytic ichthyosis.