PTEN and malignant colon neoplasm: Recently, Tay and colleagues reported that PTEN-ceRNAs, including CNOT6L and VAPA, phenocopied PTENP1 activity, as downregulation of these non-coding transcripts in prostate and colon cancer cells were also able to modulate PTEN expression, Akt activity, and cell growth (Tay et al., 2011).