Human DcR3 (hDcR3) decreased the diffuse infiltration of T cells, monocytes/macrophages, and proinflammatory cytokines in the ACGN mouse model, but the hDcR3 level in serum was extremely high in this animal model, exceeding the range of DcR3 in healthy subjects and CKD patients11, 14. Here, TNFRSF6B is linked to chronic kidney disease.