Although these tests are excellent in aiding the clinical determination of AHF and providing prognosis, it has been shown that a reduction in BNP/N-terminal of the prohormone brain natriuretic peptide (BNP/NT-proBNP) is not necessarily associated with freedom from AKI or a reduction in the risk for readmission or death over the short term. This evidence concerns the gene NPPB and acute kidney injury.