In addition to associate with malignant phenotype for high expression of wild type of Malat1 RNA, the mutated forms of Malat1 are also involved in malignant phenotype; for example, t (11; 19) (q13.1; q13.42) was been found in mesenchymal hamartoma of liver [22], this translocation causes breakpoint in Malat1 gene on chromosome 11, thereafter produces mutated forms of Malat1RNA by fusing Malat1 with MHLB1 gene of chromosome 19. The gene discussed is MALAT1; the disease is liver mesenchymal hamartoma.