HSP90 has been shown to be upregulated in a wide variety of tumors including breast tumors [42] to aid in folding and stabilization of various over-expressed or mutant tumor associated proteins such as EGFR [43], mutant B-Raf [44], mutant BRCA1 [45] and mutant p53 [46]. This evidence concerns the gene HSP90AA1 and breast neoplasm.