Our data reveal similar IL28B genotypes distribution in HCV patients with circulating cryoglobulins as compared to chronic HCV patient without, in good agreement with previous report suggesting that genetic variations in IL28B genes proximity do not influence the development of cryoglobulinemia.18 Nevertheless, a different distribution of IL28B genotypes has been reported by a recent study, even though this result may be dependent on the geographical origin of the enrolled patients.20 The gene discussed is IFNL3; the disease is cryoglobulinemia.