The rs12979860/rs8099917 IL28B polymorphisms have also been analyzed in a large, prospective study of HCV-positive patients with and without MC confirming IL28B genotype as a strong independent predictor of response to interferon-based therapy also in MC patients.19 The influence of IL28B rs8099917/rs12979860 on the presence of MC and response to PR treatment was retrospectively examined on 541 patients with chronic hepatitis, 175 of whom with MC. The gene discussed is IFNL3; the disease is chronic hepatitis.