FCRL3 and Graves disease: An association was observed between a short segment composed of 4 SNPs (FCRL3_3, FECRL3_4, FCRL3_5, and FCRL3_6) in FCRL3 and RA.21 Simmonds et al28 also found that mutations of FCRL3_3 (OR = 1.17 [95% CI: 1.02–1.34]), FCRL3_5 (OR = 1.18 [95% CI: 1.04–1.35]), and FCRL3_6 (OR = 1.20 [95% CI: 1.05–1.36]) could heighten susceptibility of Graves’ disease by means of altering pathways of B cell signaling and activation.