TNFSF10 and Hypertension: Adding the plasma TRAIL level into the multivariate model of variables for which LAA patients and controls differd, such as hypertension, smoking, alcohol consumption, and TC, hs-CRP, HDL and GLU levels, the AUC increased from 0.639 to 0.785 (Fig 3), but the change was not statistically significant (P = 0.146).