In Chinese populations, the CDKN2A-rs10811661 polymorphism was associated with increased risk in both prediabetes (OR = 1.23, 95 % CI = 1.11–1.36) and T2D (OR = 1.46, 95 % CI = 1.01–2.11) in a case–control study and confirmed in a prospective study that the risk allele of rs10811661 increased the risk of incident T2D by 94 % [25]. This evidence concerns the gene CDKN2A and prediabetes syndrome.