CDKN2A and obesity due to melanocortin 4 receptor deficiency: In the present study, the association between the CDKN2A-rs10811661 polymorphism and prediabetes was consistently significant when adding each of the obesity − related traits in the analysis models including age, gender, systolic blood pressure, socio-economic status and lifestyle factors, indicating the direct effect of the CDKN2A-rs10811661 polymorphism on prediabetes, independently of the obesity–related traits.