Although previous studies have examined various techniques for non-invasive detection of EGFR mutations in NSCLC patients, such as amplification refractory mutation systems, denaturing high-performance liquid chromatography, multi-threaded electronic polymerase chain reaction, and direct sequencing, the results have been inconclusive, with sensitivities ranging from 43.1% to 81.2% [16–23]. Here, EGFR is linked to non-small cell lung carcinoma.