It has been recognized that the inflammatory mediators associated with aqueous tear deficiency dry eye included Th1-related cytokines (e.g INF-alpha), Th17-related cytokines, chemokines and theirreceptors, metalloproteinase, and secretory phospholipases (e.g IL-1β, IL-6, IFN-γ and TNF-α) and MMPs.[57, 59–63]We analyzed the tear cytokines (IL-8, IL-17 and TNF-α), and found a time dependent increase of these three cytokines after exposure, which was correlated to the time dependent change of the inflammatory cellular infiltration revealed by in vivo confocal microscopy. Here, TNF is linked to Keratoconjunctivitis sicca.