The first study evaluated the influence of the APOE genotype on the accuracy of AD risk assessment using NRI and found a significant improvement (NRI 0.18, ZNRI = 2.47, P = 0.01) compared to a non-APOE model; the IDI was estimated as 6.25 (ZIDI = 3.75, P <0.001)[15]. The gene discussed is APOE; the disease is Alzheimer disease.