Results from stratified analysis suggest that unique dementia risk prediction models may need to be developed depending on follow-up length (e.g., BMI and hypertension may be more important in mid-life compared to later life models)[7, 23, 26, 36–38], an individual’s education level (found in one study and requires replication) [7], health status (e.g., diabetes)[13], APOE status[23] and the outcome tested (e.g., most studies focus on all-cause dementia and different models maybe needed depending on dementia subtype)[19]. Here, APOE is linked to hypertensive disorder.