ZEB1 and esophageal squamous cell carcinoma: As shown in Figure 2A–2B, the expression of miR-200b was substantially decreased in 6/7 ESCC cell lines as compared to an immortalized esophageal cell line (P < 0.01), and a low expression of miR-200b was associated with a high expression of ZEB1/2 mRNA in this panel of ESCC cell lines (P < 0.05).