As shown in Figure 6A–6B, Kindlin-2 expression was positively correlated with the activation of both the integrin signaling pathway and the PI3K-AKT signaling pathway in two independent cohorts of ESCC patients (both P < 0.01, n = 20 and n = 53, respectively). The gene discussed is FERMT2; the disease is esophageal squamous cell carcinoma.