Next, we used the same strategy to test the PR8-HY backbone with the wild-type or chimeric HA and NA genes of A/Anhui/1/2013 (H7N9) virus, a representative of the recently emerged H7N9 viruses that have caused severe respiratory infections in humans with high-case fatality rates2, 3. The gene discussed is KDM5D; the disease is respiratory tract infectious disorder.