TKS5 knockdown abolishes invadopodia formation and extracellular matrix degradation in human breast cancer and melanoma cells [37] and inhibits the formation of lung metastases by SRC-transformed mouse fibroblasts and Ras-transformed human mammary epithelial cells after tail vein injection or subcutaneous transplantation [14, 52]. This evidence concerns the gene SH3PXD2A and melanoma.