Moreover, unlike Mamu-KIR3DL05, which appears to be associated with elevated viral loads in SIV-infected animals [48], certain highly expressed alleles of KIR3DL1, in combination with their HLA-Bw4 ligands, are associated with lower viral loads and slower progression to AIDS in HIV-1 infected individuals [9]. Here, KIR3DL1 is linked to AIDS.