The DPR positively correlated with the CSF level of IFN-γ in both the ALS <12 m (r = 0.5441, P = 0.0240, Fig 3B) and ALS≥12 m (r = 0.6883, P<0.0001, Fig 3C) subgroups. Here, IFNG is linked to amyotrophic lateral sclerosis.