The levels of IFN-γ in serum were also reported in other different diseases, Medina et al reported that the IFN-γ level was higher in P. vivax-infected patients with increased disease severity [21], Liu et al found IFN-γ overcomes the resistance of tumor cell apoptosis by regulating the expression of apoptosis-related genes [22]. This evidence concerns the gene IFNG and neoplasm.