On the other hand, the genetic association of the major histocompatibility complex (MHC) class I chain related to gene A (MICA) with BD has been reported in various ethnic groups [15, 16], and a strong association of the polymorphism in the transmembrane region of MICA (MICA*009) with BD was observed [17, 18]. This evidence concerns the gene HLA-C and Behcet disease.