Therefore, we aimed to investigate the link between BD and two specific HLA alleles associated with BD (HLA-A*26:01 and HLA-B*51:01) in terms of their binding affinity to the MICA-TM peptide using MD simulations, in comparison with two HLA alleles not associated with BD (HLA-A*11:01 and HLA-B*35:01). Here, HLA-A is linked to Behcet disease.