Herein, we aimed to search for the selective correlation between the two BD-associated HLA alleles (HLA-A*26:01 and HLA-B*51:01) and the MICA-TM peptide in comparison with two class matched non-BD-associated HLA alleles (HLA-A*11:01 and HLA-B*35:01) by MD simulations. This evidence concerns the gene HLA-A and Behcet disease.