They stipulated that the decreased plasma osmolality at the end of treatment of enuretic children with rapid palatal expansion was assumed to be consequence of increased ADH level.[26] Other possible mechanisms are improved neuromuscular coordination and lesser deep phase of sleep related to a higher oxygen saturation level derived by smoother and higher nasal airflow.[23] More recently, Sans Capdevila et al. found that higher brain natriuretic peptide is secreted in cases with either obstructive sleep apnea or enuresis. This evidence concerns the gene AVP and obstructive sleep apnea syndrome.