Currently, many GBM cells show resistance to TRAIL-induced apoptosis due to various reasons, including low expression of DR4 and DR5 (Knight et al. 2001; Kuijlen et al. 2006), the up-regulation of anti-apoptotic proteins such as c-Flip, Bcl-2 and survivin (Knight et al. 2001; Kouri et al. 2012; Song et al. 2003; Xie et al. 2006; Fulda et al. 2002), or the down-regulation of critical pro-apoptotic proteins such as caspase-8 and Bak (Knight et al. 2001; Song et al. 2003; Capper et al. 2009; Qi et al. 2011). This evidence concerns the gene CASP8 and glioblastoma.