TNFSF10 and cancer: Recently, an increasing number of reports have shown the therapeutic relevance of inducers of endoplasmic reticulum (ER) stress in cancer, also as sensitizers for TRAIL-based therapies (Chen et al. 2007; Zhou et al. 2013; Yoon et al. 2013; Martin-Perez et al. 2012; Kim et al. 2011; Tian et al. 2011; Gaiser et al. 2008).