Recently, the use of ER stress inducers, like DMC, have raised great interest as potential anti-cancer agents and sensitizers for TRAIL-based therapies, since ER stress was reported to down-regulate important anti-apoptotic proteins, including c-Flip (Chen et al. 2007; Zhou et al. 2013; Yoon et al. 2013; Martin-Perez et al. 2012), Bcl-2 (Zhou et al. 2013; Lee et al. 2008; McCullough et al. 2001) and survivin (Zhou et al. 2013; Gaiser et al. 2008). Here, BCL2 is linked to cancer.