In contrast to Chudley-McCullough syndrome, α-dystroglycanopathies, GPR56-related polymicrogyria, and Poretti-Boltshauser syndrome, in Lhermitte-Duclos disease the orientation of the cerebellar foliae is preserved, while the volume of multiple cerebellar foliae is diffusely increased [37]. Here, ADGRG1 is linked to Ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome.