SNCA and multiple system atrophy: Genetic inheritance is uncommon and there are few reports of familiar MSA in the literature [49-51]; however, the genetic background is important and single nucleotide polymorphisms (SNPs) of the genes encoding α-synuclein [52-54], the prion protein [55], and loss of function mutations of the phenylbenzoate-polyprenyltransferase were shown to be associated with an increased risk of MSA [38].