Similarly, in several Drosophila models of human polyQ disorders including SCA3/MJD, SCA1 and HD, Mallik et al. [50] discovered that RNAi suppress pathogenesis of polyQ diseases by down-regulating transcripts of hsr-ω, a dominant modifier for polyQ pathogenic mechanism found in Drosophila model of SCA1 [42]. The gene discussed is ATXN1; the disease is Huntington disease.