Many mutations lead to a change in spatiotemporal firing patterns and motor and cognitive impairments [296], e.g. CACNA1A gene mutation in Tottering mice [245], Grik mutation in Weaver mice [137], mice selectively lacking large-conductance voltage- and calcium-activated potassium channels in the Purkinje cells [297], mice deficient in calretinin [298], etc. In calretinin deficient mice, motor coordination was restored with selective re-expression of calretinin in granule cells [299]. This evidence concerns the gene CALB2 and Cognitive impairment.