TET2 was also modestly increased in the T cells of RA patients in relation with the healthy controls (Fig. 3d; mean = 3.4, 95 % CI = 2.4–5.2 vs. 2.2, 95 % CI = 1.8–3.0; P = 0.045). The gene discussed is TET2; the disease is rheumatoid arthritis.