Idylla detected BRAF V600 mutations (4.6% V600E and 5.7% V600R according to MiSeq) in two samples that had relatively low tumor cellularity and that cobas identified as having wild-type BRAF, plausibly due to the test's higher detection limit (at least 5% of V600E mutant DNA) and because cobas is not validated for the detection of V600R. Here, BRAF is linked to neoplasm.