In multivariate analysis, the logistic regression model was adjusted for age, gender, WBC, ALC, PCT concentrations, the MEDS score, the percentage of BTLA+/CD4+T cells , and MFI of BTLA on CD4+ T cells, to determine the relationship of 28-day mortality in patients with sepsis, severe sepsis and septic shock. This evidence concerns the gene BTLA and Sepsis.