The clinical significance of this is underscored by the findings of Antonarakis et al. [93], who demonstrated that the presence of ARV7 in circulating tumor cells in patients treated with enzalutamide or abiraterone had a significantly lower prostate-specific antigen (PSA) response, shorter progression-free survival, and shorter overall survival compared to men without ARV7. This evidence concerns the gene KLK3 and neoplasm.