Taxane efficacy following AR targeted therapy is also blunted, as demonstrated by van Soest et al. [110, 111] – docetaxel inhibited tumor growth, AR nuclear translocation, AR regulated gene expression, and PSA levels in enzalutamide-naïve tumors in castrated mice but not in enzalutamide-resistant tumors. This evidence concerns the gene KLK3 and neoplasm.