Proliferation of CD4+ T cells (% of proliferating cells ± SD: 84.06 ± 20.27) was significantly inhibited in the presence of melanoma cells at 1:8 (29 ± 17.1, p = 0.0001) or 1:16 (38.9 ± 11, p = 0.0008) melanoma:CD4+ T cell ratios (Figure 3, panel A). This evidence concerns the gene CD4 and melanoma.