CD4+ T lymphocytes proliferation (% of proliferating cells ± SD: 84.06 ± 20.27) was significantly inhibited in the presence of melanoma cells either at 1:8 (24.28 ± 7.75, p = 0.0008) or 1:16 (36.3 ± 6.89, p = 0.005) melanoma:CD4+ T cell ratios. Here, CD4 is linked to melanoma.